BiologicalActivity
Highlypotentandselective5-HTuptakeinhibitorthatbindswithhighaffinitytotheSEROtonintransporter(Ki=0.05nM).Kivaluesare1.1,350and1100nMforinhibitionof[3H]-5-HT,[3H]-l-NAand[3H]-DAuptakerespectively.Displaysminimalaffinityforα1-,α2-orβ-adrenoceptors,5-HT2A,5-HT1A,D2orH1receptorsatconcentrationsbelow1000nM,howeverdisplaysweakaffinityformuscarinicAChreceptors(Ki=42nM).Antidepressantandanxiolyticinvivo.
TechnicalData
| M.Wt | 445.44 |
| Formula | C19H20FNO3.C4H4O4 |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 64006-44-6 |
| PubChemID | 6435921 |
| InChIKey | AEIUZSKXSWGSRU-QXGDPHCHSA-N |
| Smiles | OC(=O)C=C/C(O)=O.FC1=CC=C(C=C1)[C@@H]1CCNC[C@H]1COC1=CC2=C(OCO2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 44.54 | 100 | |
| ethanol | 44.54 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight445.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.24mL | 11.22mL | 22.45mL |
| 5mM | 0.45mL | 2.24mL | 4.49mL |
| 10mM | 0.22mL | 1.12mL | 2.24mL |
| 50mM | 0.04mL | 0.22mL | 0.45mL |
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