BiologicalActivity
PotentandselectiveGlyT1inhibitor(IC50=92nM).Exhibits50-foldselectivityoverGlyT2.AttenuatesMK801-inducedworkingmemorydeficitsandPCP-inducedvisuallearningdeficitsinmice.Orallyavailableandbrainpenetrant.
CompoundLibraries
ASP2535isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 382.42 |
| Formula | C22H18N6O |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 374886-51-8 |
| PubChemID | 9800113 |
| InChIKey | FQGLDGKVKDPVLO-UHFFFAOYSA-N |
| Smiles | CC(C)C1=NN=C(C4=CN=C(C5=CC=CC=C5)C=C4)N1C3=CC=CC2=NON=C23 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.24 | 100 | |
| ethanol | 38.24 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight382.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.61mL | 13.07mL | 26.15mL |
| 5mM | 0.52mL | 2.61mL | 5.23mL |
| 10mM | 0.26mL | 1.31mL | 2.61mL |
| 50mM | 0.05mL | 0.26mL | 0.52mL |
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