进口试剂Tocris直采正品Tocris Bioscience生物试剂1,Tocris/Andrographolide/4626/50/50 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/Andrographolide/4626/50/50 mg

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Tocris

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4626/50

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4000-520-616

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Description:InhibitsNFκB;blocksandrogenreceptor(AR)expression

ChemicalName:(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethylidene]dihydro-4-hydroxy-2(3H)-furanone

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofNF-κBsignaling;alsoattenuatesconcanavaline-inducedIFNγproductioninmurineTcells(IC₅₀=1.7μM).Blocksandrogenreceptor(AR)expressioninAR-expressingC4-2cells.ActivatesNrf2inBEAS-2Bcellsinresponsetocigarettesmokeextract.

TechnicalData

M.Wt	350.45
Formula	C₂₀H₃₀O₅
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	5508-58-7
PubChemID	452937
InChIKey	BOJKULTULYSRAS-UQZPWQSVSA-N
Smiles	C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC3)([H])[C@]3(C)[C@@H]1C/C=C2[C@H](O)COC/2=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	35.05	100
	ethanol	3.5	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight350.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.85mL	14.27mL	28.53mL
5mM	0.57mL	2.85mL	5.71mL
10mM	0.29mL	1.43mL	2.85mL
50mM	0.06mL	0.29mL	0.57mL

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