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Tocris/Ani 9/6076/50/50 mg

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Tocris

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6076/50

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Description:PotentandselectiveTMEM16A(Anoctamin-1;ANO1)blocker

ChemicalName:2-(4-Chloro-2-methylphenoxy)-N'-(2-methoxybenzylidene)acetohydrazide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveTMEM16A(Anoctamin-1;ANO1)blocker(IC₅₀=77nM).DisplaysnoeffectonANO2activity(at10μM).AlsoexhibitsnoeffectonintracellularcalciumsignalingorCFTRandENaCchannelactivity(at30μM).

TechnicalData

M.Wt	332.78
Formula	C₁₇H₁₇ClN₂O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	356102-14-2
PubChemID	9556542
InChIKey	KDALDZRKOBJXIE-VXLYETTFSA-N
Smiles	COC1=C(C=CC=C1)/C=N/NC(COC2=C(C=C(C=C2)Cl)C)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	33.28	100
	ethanol	3.33	10mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight332.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3mL	15.02mL	30.05mL
5mM	0.6mL	3mL	6.01mL
10mM	0.3mL	1.5mL	3mL
50mM	0.06mL	0.3mL	0.6mL

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