BiologicalActivity
Macrophagemigrationinhibitoryfactor(MIF)binder(Kd=68.6nM).Activatesantioxidantresponseelement(ARE)-mediatedgeneexpression.Suppressesoxidativestress-inducedcardiomyocyteapoptosisinvitro.Cardioprotective.
TechnicalData
| M.Wt | 240.28 |
| Formula | C13H8N2OS |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 99420-15-2 |
| PubChemID | 9837640 |
| InChIKey | GBAKVEWPYUIGHN-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1SC(C3=NC=CC=C3)=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.81 | 20mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight240.28.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.16mL | 20.81mL | 41.62mL |
| 5mM | 0.83mL | 4.16mL | 8.32mL |
| 10mM | 0.42mL | 2.08mL | 4.16mL |
| 50mM | 0.08mL | 0.42mL | 0.83mL |
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