BiologicalActivity
Novelsubtype-selectiveandweaklydesensitizingAMPAreceptorpartialagonist(Kivaluesare44,109,223,1890and2090nMatGluR5,GluR1,GluR2,GluR3andGluR4receptorsrespectively).ExhibitspotentagonistactivityatGluR1andGluR2subunit-containingAMPAreceptors(EC50valuesare24.9and13.9μMrespectively)andisexcitotoxicinvitro.
TechnicalData
| M.Wt | 239.23 |
| Formula | C10H13N3O4 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 389888-02-2 |
| PubChemID | 657004 |
| InChIKey | VSGUEKZRMJVQOH-LURJTMIESA-N |
| Smiles | O=C1NC(C2=C(CCC2)N1C[C@H](N)C(O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 11.96 | 50 | |
| water | 11.96 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight239.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.18mL | 20.9mL | 41.8mL |
| 5mM | 0.84mL | 4.18mL | 8.36mL |
| 10mM | 0.42mL | 2.09mL | 4.18mL |
| 50mM | 0.08mL | 0.42mL | 0.84mL |
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