BiologicalActivity
mSTINGagonist;selectiveformouseSTINGoverhumanSTING.InducesIFN-βandcytokineproductionfrombonemarrow-deriveddendriticcells.Causestumorregressionfollowingintratumoraladministrationinmousetumormodels.Inducesanadaptiveimmuneresponsetoreducesystemictumorgrowthandprovidesimmunologicalmemoryagainstautologoustumorre-challenge.Alsoantiviral.
TechnicalData
| M.Wt | 282.29 |
| Formula | C17H14O4 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 117570-53-3 |
| PubChemID | 123964 |
| InChIKey | XGOYIMQSIKSOBS-UHFFFAOYSA-N |
| Smiles | O=C1C2=CC=CC(CC(O)=O)=C2OC3=C1C=CC(C)=C3C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.65 | 20 | |
| ethanol | 1.41 | 5mMwithsonication |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight282.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.54mL | 17.71mL | 35.42mL |
| 5mM | 0.71mL | 3.54mL | 7.08mL |
| 10mM | 0.35mL | 1.77mL | 3.54mL |
| 50mM | 0.07mL | 0.35mL | 0.71mL |
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ProductDatasheets
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