进口Tocris品牌清关代理 Tocris Bioscience一级代理,Tocris/GANT 58/3889/50/50 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/GANT 58/3889/50/50 mg

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Tocris

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3889/50

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4000-520-616

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Description:GLI1antagoNIST;inhibitsHedgehog(Hh)signaling

ChemicalName:2,3,4,5-Tetra(4-pyridyl)thiophene

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

GLIantagonistthatinhibitsGLI1-inducedtranscription(IC₅₀=5μM).Inhibitsthehedgehog(Hh)signalingpathwaydownstreamofSMOandSUFUcausingGLI1nuclearaccumulation.Displaysantiproliferativeandantitumoractivityinvivo.

CompoundLibraries

GANT58isalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	392.48
Formula	C₂₄H₁₆N₄S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	64048-12-0
PubChemID	253078
InChIKey	USWLOKMMUTWFMD-UHFFFAOYSA-N
Smiles	C1(C5=CC=NC=C5)=C(C3=CC=NC=C3)C(C2=CC=NC=C2)=C(C4=CC=NC=C4)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	9.81	25
	ethanol	9.81	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight392.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.55mL	12.74mL	25.48mL
5mM	0.51mL	2.55mL	5.1mL
10mM	0.25mL	1.27mL	2.55mL
50mM	0.05mL	0.25mL	0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

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