BiologicalActivity
Reversible,voltage-dependentCFTRchloridechannelblocker(Ki=4.3μM).Inhibitsforskolin-inducedhyperpolarizationinnasalpotentialdifferencesandinhibitscholeratoxin-inducedintestinalfluidsecretioninmice.
TechnicalData
| M.Wt | 493.15 |
| Formula | C19H15Br2N3O3 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 328541-79-3 |
| PubChemID | 11260414 |
| InChIKey | FLGYCSPPJQJZCH-LCYFTJDESA-N |
| Smiles | O=C(N/N=C/C3=C(O)C(Br)=C(O)C(Br)=C3)CNC2=CC1=CC=CC=C1C=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 49.31 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight493.15.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.03mL | 10.14mL | 20.28mL |
| 5mM | 0.41mL | 2.03mL | 4.06mL |
| 10mM | 0.2mL | 1.01mL | 2.03mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |
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