BiologicalActivity
InhibitorofcanonicalWntpathwaysignaling(IC50=1.17μM);targetstheβ-catenindestructioncomplex(GSK-3β/AXIN/APC)toinduceβ-catenindegradation.SelectiveforthecanonicalWntpathwayovertheSonichedgehog(Shh)andNF-κBpathways.BlocksG1/Scellcycleprogressionincolorectalcancer(CRC)celllines(GI50=7.8μM).
CompoundLibraries
JW67isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 394.38 |
| Formula | C21H18N2O6 |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 442644-28-2 |
| PubChemID | 644733 |
| InChIKey | BTXRSHKJNDFHGA-UHFFFAOYSA-N |
| Smiles | O=C1NC6=C(C=CC=C6)C21OCC3(COC(C(NC5=C4C=CC=C5)=O)4OC3)CO2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight394.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.54mL | 12.68mL | 25.36mL |
| 5mM | 0.51mL | 2.54mL | 5.07mL |
| 10mM | 0.25mL | 1.27mL | 2.54mL |
| 50mM | 0.05mL | 0.25mL | 0.51mL |
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