正品Tocris生物试剂1 Tocris Bioscience产品目录价格,Tocris/Jervine/4717/10/10 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/Jervine/4717/10/10 mg

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Tocris

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4717/10

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4000-520-616

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Description:InhibitorofHedgehog(Hh)signaling;bindsdirectlytoSmo

ChemicalName:(2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11a,11b-hexadecahydro-3-hydroxy-3',6',10,11b-tetramethyl-Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

InhibitorofHedgehogsignaling(IC₅₀=500-700nM);bindsdirectlytoSmoothened(Smo).InhibitstheresponseoftargettissuestoSonichedgehogsignaling,possIBLyviathesterolsensingdomainofPatched.Teratogenic.

TechnicalData

M.Wt	425.6
Formula	C₂₇H₃₉NO₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	469-59-0
PubChemID	10098
InChIKey	CLEXYFLHGFJONT-DNMILWOZSA-N
Smiles	O[C@H](C2)CC[C@@]1(C)C2=CC[C@]([C@@](CC[C@@]54O[C@@](C[C@H](C)CN6)([H])[C@]6([H])[C@H]5C)([H])C3=[C@@]4C)([H])[C@@]([H])1C3=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	8.51	20
	ethanol	21.28	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight425.6.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.35mL	11.75mL	23.5mL
5mM	0.47mL	2.35mL	4.7mL
10mM	0.23mL	1.17mL	2.35mL
50mM	0.05mL	0.23mL	0.47mL

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BiologicalActivity

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PreparingStockSolutions

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