BiologicalActivity
Potent,reversiblenon-steroidalaromataseinhibitor(IC50=11.5nM).Displaysantitumoreffectsinseveralanimalmodels.Suppressestheendogenousaromatase-inducedproliferationofMCF-7cells.
CompoundLibraries
LetrozoleisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 285.3 |
| Formula | C17H11N5 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 112809-51-5 |
| PubChemID | 3902 |
| InChIKey | HPJKCIUCZWXJDR-UHFFFAOYSA-N |
| Smiles | N#CC(C=C2)=CC=C2C(N3N=CN=C3)C1=CC=C(C#N)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight285.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.51mL | 17.53mL | 35.05mL |
| 5mM | 0.7mL | 3.51mL | 7.01mL |
| 10mM | 0.35mL | 1.75mL | 3.51mL |
| 50mM | 0.07mL | 0.35mL | 0.7mL |
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