BiologicalActivity
Cell-permeable,genotype-selectiveantitumoragentthatactivatesp53-dependenttranscription.Increaseslevelsofendogenousp53intumorcellsandprotectsp53fromMdm2-mediateddegradation.Displayssomeselectivityfortumorcellsvs.normalcellsinanMTTcellviABIlityassay.
TechnicalData
| M.Wt | 316.85 |
| Formula | C17H16N2S.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 59474-01-0 |
| PubChemID | 5458312 |
| InChIKey | VIBMUYOXJUCEMA-UHFFFAOYSA-N |
| Smiles | N=C(N)SCC1=C(C=CC=C3)C3=C(C)C2=C1C=CC=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.68 | 100 | |
| ethanol | 3.17 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight316.85.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.16mL | 15.78mL | 31.56mL |
| 5mM | 0.63mL | 3.16mL | 6.31mL |
| 10mM | 0.32mL | 1.58mL | 3.16mL |
| 50mM | 0.06mL | 0.32mL | 0.63mL |
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