Tocris型号参数规格 Tocris信号通路抑制剂,Tocris/PIT 1/4168/50/50 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/PIT 1/4168/50/50 mg

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Tocris

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4168/50

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4000-520-616

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Description:PIP₃antagoNIST.BlocksPIP₃-PHinteraction;inhibitsAktsignaling

ChemicalName:N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectivePIP₃antagonist.BlocksthebindingofPIP₃tothepleckstrinhomology(PH)domainofAkt(IC₅₀=31.03μM).InhibitscancercellsurvivalandinducesapoptosisbyinhibitionofPIP₃-dependentPI3-kinase/Aktsignaling.Exhibitsantitumoractivityinvivo.

TechnicalData

M.Wt	351.76
Formula	C₁₄H₁₀ClN₃O₄S
Storage	Storeat+4°C
Purity	≥99%(HPLC)
CASNumber	53501-41-0
PubChemID	3664359
InChIKey	RIGXBXPAOGDDIG-UHFFFAOYSA-N
Smiles	ClC1=C(O)C(NC(NC(C2=CC=CC=C2)=O)=S)=CC([N+]([O-])=O)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	26.38	75
	ethanol	3.52	10

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight351.76.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.84mL	14.21mL	28.43mL
5mM	0.57mL	2.84mL	5.69mL
10mM	0.28mL	1.42mL	2.84mL
50mM	0.06mL	0.28mL	0.57mL

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