BiologicalActivity
Selectivelyrestoresmutantp53activityintumorcellsviaactivationofBaxandPUMA.Inducesapoptosisandinhibitsgrowthoftumorswithmutantp53.
TechnicalData
| M.Wt | 185.22 |
| Formula | C9H15NO3 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 5608-24-2 |
| PubChemID | 322968 |
| InChIKey | RFBVBRVVOPAAFS-UHFFFAOYSA-N |
| Smiles | O=C1C(CO)(CO)N2CCC1CC2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| phosphatebufferedsaline | 18.52 | 100 | |
| water | 18.52 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight185.22.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 5.4mL | 26.99mL | 53.99mL |
| 5mM | 1.08mL | 5.4mL | 10.8mL |
| 10mM | 0.54mL | 2.7mL | 5.4mL |
| 50mM | 0.11mL | 0.54mL | 1.08mL |
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