BiologicalActivity
p53stabilizingagent;preferentiallybindsmutated(Y220C)p53overwild-typep53atasitedistinctfromfunctionalDNA/proteininteractionregions.Slowsrateofthermaldenaturationofp53-Y220C.
CompoundLibraries
PhiKan083isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 274.79 |
| Formula | C16H18N2.HCl |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 880813-36-5 |
| PubChemID | 16255105 |
| InChIKey | IXWVUPURFWFRNE-UHFFFAOYSA-N |
| Smiles | CCN1C3=C(C=CC=C3)C2=C1C=CC(CNC)=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.48 | 100 | |
| ethanol | 13.74 | 50 | |
| water | 13.74 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight274.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.64mL | 18.2mL | 36.39mL |
| 5mM | 0.73mL | 3.64mL | 7.28mL |
| 10mM | 0.36mL | 1.82mL | 3.64mL |
| 50mM | 0.07mL | 0.36mL | 0.73mL |
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ProductDatasheets
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