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Description:Antitumoragent;suppressesmutantp53-bearingcancercells
ChemicalName:2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanonehydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Antitumoragent.Inhibitstumorcellgrowthinamutantp53-andp73-dependentmannerinvitroandinvivo(IC50=4μM).Transcriptionallyactivatesexpressionofp53-responsivegenesandinducesactivationofeffectorcaspases3and7.
TechnicalData
M.Wt | 305.8 |
Formula | C11N11NO3S2.HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1173023-52-3 |
PubChemID | 46861546 |
InChIKey | ZZAVDVMJZKDBIB-UHFFFAOYSA-N |
Smiles | OC1=CC(C(CSC2=NCCS2)=O)=CC=C1O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.58 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight305.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.27mL | 16.35mL | 32.7mL |
5mM | 0.65mL | 3.27mL | 6.54mL |
10mM | 0.33mL | 1.64mL | 3.27mL |
50mM | 0.07mL | 0.33mL | 0.65mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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