Tocris神经传递素 Tocris小分子,Tocris/SANT-1/1974/10/10 mg,信号通路,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/SANT-1/1974/10/10 mg

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Tocris

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1974/10

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4000-520-616

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Description:Inhibitorofhedgehog(Hh)signaling;antagonizessmoothenedactivity

ChemicalName:N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potent,cell-permeableinhibitorofSonichedgehog(Shh)signaling;highaffinityantagoNISTofsmoothenedactivity(K_D=1.2nM).InhibitssmoothenedagonisteffectswithanIC₅₀of20nM(inShh-LIGHT2cells).

CompoundLibraries

SANT-1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	373.5
Formula	C₂₃H₂₇N₅
Storage	Desiccateat+4°C
Purity	≥99%(HPLC)
CASNumber	304909-07-7
PubChemID	6878030
InChIKey	FOORCIAZMIWALX-JJIBRWJFSA-N
Smiles	CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	18.68	50
	ethanol	9.34	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight373.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.68mL	13.39mL	26.77mL
5mM	0.54mL	2.68mL	5.35mL
10mM	0.27mL	1.34mL	2.68mL
50mM	0.05mL	0.27mL	0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

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BiologicalActivity

CompoundLibraries

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PreparingStockSolutions

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