BiologicalActivity
InhibitorofSonichedgehog(Shh)signaling;antagonizessmoothenedreceptoractivity(KD=12nM).DisplaysallostericbindingcharacteristicssimilartoSANT-1(Cat.No.1974).Displacessmo-[3H]SAG-1.3and-[3H]Cyclopaminebinding(Kivaluesare7.8nMand8.4nMrespectively).
CompoundLibraries
SANT-2isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 479.96 |
| Formula | C26H26ClN3O4 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 329196-48-7 |
| PubChemID | 1367095 |
| InChIKey | VQOJFGFKIVFMDH-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C4=CC(OCC)=C(OCC)C(OCC)=C4)=O)C=C1C3=NC2=CC=CC=C2N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48 | 100 | |
| ethanol | 48 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight479.96.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.08mL | 10.42mL | 20.84mL |
| 5mM | 0.42mL | 2.08mL | 4.17mL |
| 10mM | 0.21mL | 1.04mL | 2.08mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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