BiologicalActivity
Neuroprotectiveandneuroregenerativecompound.Rescuesmotorneuronsfromaxotomy-inducedcelldeathandpromotesnerveregenerationfollowingsciaticnervecrushinvivo.BindsdirectlytotwocomponentsofthemitochondrialpermeABIlitypore,thevoltage-dependentanionchannel(VDAC)andtranslocatorprotein;thoughttoinhibitMPTPopening.
TechnicalData
| M.Wt | 399.65 |
| Formula | C27H45NO |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 22033-87-0 |
| PubChemID | 76971721 |
| InChIKey | QNTASHOAVRSLMD-GYKMGIIDSA-N |
| Smiles | [H][C@@]23CCC1=CC(CC[C@@](C)1[C@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]([H])4[C@@H](CCCC(C)C)C)=NO |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.98 | 50 | |
| ethanol | 7.99 | 20 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight399.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.5mL | 12.51mL | 25.02mL |
| 5mM | 0.5mL | 2.5mL | 5mL |
| 10mM | 0.25mL | 1.25mL | 2.5mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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