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Description:Piezo1channelactivator
ChemicalName:2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiADIazol-2-yl]pyrazine
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
Piezo1channelactivator.Slowstheinactivationphaseoftransientcurrents,sensitizesPiezo1toactivationbypressure,andpartiallyactivateschannelsintheabsenceofexternalpressure,inHEKcellsexpressingPiezo1channels.
CompoundLibraries
Yoda1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
M.Wt | 355.27 |
Formula | C13H8Cl2N4S2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 448947-81-7 |
PubChemID | 2746822 |
InChIKey | BQNXBSYSQXSXPT-UHFFFAOYSA-N |
Smiles | ClC1=C(CSC2=NN=C(C3=NC=CN=C3)S2)C(Cl)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 17.76 | 50 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight355.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.81mL | 14.07mL | 28.15mL |
5mM | 0.56mL | 2.81mL | 5.63mL |
10mM | 0.28mL | 1.41mL | 2.81mL |
50mM | 0.06mL | 0.28mL | 0.56mL |
MolarityCalculator
MolarityCalculator
Calculatethemass,volume,orconcentrationrequiredforasolution.
ReconstitutionCalculator
ReconstitutionCalculator
DilutionCalculator
DilutionCalculator
Calculatethedilutionrequiredtoprepareastocksolution.
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet


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