BiologicalActivity
PotentandselectiveP2X7receptorantagonist(IC50valuesare18and40nMforratandhumanreceptorsrespectively).DisplaysselectivityoveravarietyofP2XandP2Yreceptorsuptoaconcentrationof100μM.Reducesnociceptioninanimalmodelsofpersistentneuropathicandinflammatorypain.Alsoreducesneuroblastomatumorgrowthinmice.
CompoundLibraries
A740003isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 474.55 |
| Formula | C26H30N6O3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 861393-28-4 |
| PubChemID | 11351968 |
| InChIKey | PUHSRMSFDASMAE-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C(NC(CC3=CC(OC)=C(OC)C=C3)=O)N/C(NC2=CC=CC1=NC=CC=C12)=N/C#N |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.49 | 20 | |
| ethanol | 2.37 | 5mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight474.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.11mL | 10.54mL | 21.07mL |
| 5mM | 0.42mL | 2.11mL | 4.21mL |
| 10mM | 0.21mL | 1.05mL | 2.11mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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