BiologicalActivity
Positiveallostericmodulatorofα7nAChRs(IC50valuesare0.98and1.12μMforhumanandratα7receptorACh-evokedcurrentsrespectively,inX.laevisoocytes).Displaysnoactivityat5-HT3A,α3β4orα4β2nAChRs.Brainpenetrant.
CompoundLibraries
A867744isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 402.89 |
| Formula | C20H19ClN2O3S |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1000279-69-5 |
| PubChemID | 23642319 |
| InChIKey | ABACVOXFUHDKNZ-UHFFFAOYSA-N |
| Smiles | O=C(CC)C1=C(C)N(C3=CC=C(S(N)(=O)=O)C=C3)C(C2=CC=C(Cl)C=C2)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.29 | 100 | |
| ethanol | 4.03 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight402.89.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.48mL | 12.41mL | 24.82mL |
| 5mM | 0.5mL | 2.48mL | 4.96mL |
| 10mM | 0.25mL | 1.24mL | 2.48mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |
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