BiologicalActivity
AselectiveandpotentGluR5kainatereceptoragonist(Ki=4.3nM),inactiveatGluR6(Ki>1mM)andonlyweaklyactiveatAMPAreceptors(GluR1-4)andthekainatereceptorsKA-2andGluR7(Kivaluesof6-14μM).AlsoavailableaspartoftheKainateReceptorTocriset™.
TechnicalData
| M.Wt | 228.25 |
| Formula | C10H16N2O4 |
| Storage | Desiccateat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 140158-50-5 |
| PubChemID | 2253 |
| InChIKey | PIXJURSCCVBKRF-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=C(CC(N)C(O)=O)C(O)=NO1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.NaOH | 22.82 | 100 | |
| water | 2.28 | 10 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight228.25.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.38mL | 21.91mL | 43.81mL |
| 5mM | 0.88mL | 4.38mL | 8.76mL |
| 10mM | 0.44mL | 2.19mL | 4.38mL |
| 50mM | 0.09mL | 0.44mL | 0.88mL |
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