Tocris中国试剂购买网站 Tocris信号通路抑制剂,Tocris/GSK 1838705/5111/50/50 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/GSK 1838705/5111/50/50 mg

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Tocris

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5111/50

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4000-520-616

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Description:PotentIRandIGF1Rinhibitor;alsoinhibitsanaplasticlymphomakinase(ALK)

ChemicalName:2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentinsulinreceptor(IR)andinsulin-likegrowthfactor-1receptor(IGF1R)inhibitor(IC₅₀valuesare1.6and2nM,respectively).Alsoinhibitsanaplasticlymphomakinase(ALK)(IC₅₀=0.5nM).Displays>800-foldselectivityforIR,IGFR1andALKoverapanelof44kinasesincludingJNK.Blocksproliferationofcancercelllinesinvitro,andcausescompleteregressionofALK-dependenttumorsinvivo.Orallybioavailable.

LicensingInformation

SoldforresearchpurposesunderagreementfromGlaxoSmithKline.

CompoundLibraries

GSK1838705isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxII.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	532.57
Formula	C₂₇H₂₉FN₈O₃
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	1116235-97-2
PubChemID	25182616
InChIKey	HZTYDQRUAWIZRE-UHFFFAOYSA-N
Smiles	O=C(CN(C)C)N4CCC(C4=C5)=CC(OC)=C5NC1=NC(NC3=C(C(NC)=O)C(F)=CC=C3)=C2C(NC=C2)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
Solubility	DMSO	53.26	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight532.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.88mL	9.39mL	18.78mL
5mM	0.38mL	1.88mL	3.76mL
10mM	0.19mL	0.94mL	1.88mL
50mM	0.04mL	0.19mL	0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet

SafetyDatasheet

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