BiologicalActivity
Inhibitorofc-Fmstyrosinekinase(M-CSFR,CSF1R)(IC50valuesare2,12,217and451nMforc-Fms,VEGFR-2,PDGFRβandc-Kitrespectively).DoesnotinhibitFlt3,EGFRorc-Src.Suppressesosteoclastdifferentiationandosteolysisinaratbonemetastasismodel.
CompoundLibraries
Ki20227isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 480.54 |
| Formula | C24H24N4O5S |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 623142-96-1 |
| PubChemID | 9869779 |
| InChIKey | SHPFDGWALWEPGS-UHFFFAOYSA-N |
| Smiles | O=C(NC(C)C3=NC=CS3)NC(C(OC)=C2)=CC=C2OC1=C4C(C=C(OC)C(OC)=C4)=NC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.05 | 100 | |
| ethanol | 4.81 | 10mMwithgentlewarming |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight480.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.08mL | 10.4mL | 20.81mL |
| 5mM | 0.42mL | 2.08mL | 4.16mL |
| 10mM | 0.21mL | 1.04mL | 2.08mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |
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