Tocris抗体，试剂，血清，细胞 Tocris小分子,Tocris/PLX 647 dihydrochloride/5102/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/PLX 647 dihydrochloride/5102/10/10 mg

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Tocris/PLX 647 dihydrochloride/5102/10/10 mg

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Tocris

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5102/10

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4000-520-616

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Description:PotentdualFms/KITinhibitor

ChemicalName:5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinaminedihydrochloride

Purity:≥97%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentdualKIT/Fmsinhibitor(IC₅₀valuesare16and28nMrespectively).InhibitsBCR-FMScellproliferationandosteoclastdifferentiationinvitro(IC₅₀valuesare92and170nMrespectively).AttenuatesLPS-inducedTNFαandIL-6release,mastcellactivationandmacrophagekidneyproliferationinvivo.

CompoundLibraries

PLX647dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt	455.3
Formula	C₂₁H₁₇F₃N₄.2HCl
Storage	Storeat-20°C
Purity	≥97%(HPLC)
CASNumber	1779796-38-1
PubChemID	78243730
InChIKey	MVMKWLRKACAUTB-UHFFFAOYSA-N
Smiles	FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	45.53	100
	ethanol	45.53	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight455.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	2.2mL	10.98mL	21.96mL
5mM	0.44mL	2.2mL	4.39mL
10mM	0.22mL	1.1mL	2.2mL
50mM	0.04mL	0.22mL	0.44mL

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