BiologicalActivity
PotentdualKIT/Fmsinhibitor(IC50valuesare16and28nMrespectively).InhibitsBCR-FMScellproliferationandosteoclastdifferentiationinvitro(IC50valuesare92and170nMrespectively).AttenuatesLPS-inducedTNFαandIL-6release,mastcellactivationandmacrophagekidneyproliferationinvivo.
CompoundLibraries
PLX647dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 455.3 |
| Formula | C21H17F3N4.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1779796-38-1 |
| PubChemID | 78243730 |
| InChIKey | MVMKWLRKACAUTB-UHFFFAOYSA-N |
| Smiles | FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.53 | 100 | |
| ethanol | 45.53 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight455.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.2mL | 10.98mL | 21.96mL |
| 5mM | 0.44mL | 2.2mL | 4.39mL |
| 10mM | 0.22mL | 1.1mL | 2.2mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |
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