BiologicalActivity
Insulin-likegrowthfactorreceptor(IGF1R)inhibitor.SuppressesIGF-stimulatedIGF-IRautophosphorylationwithanIC50valueof12μM.InhibitsgrowthofMCF-7breastcancercellsinvitroandinvivo.
CompoundLibraries
PQ401isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
TechnicalData
| M.Wt | 341.79 |
| Formula | C18H16ClN3O2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 196868-63-0 |
| PubChemID | 9549305 |
| InChIKey | YBLWOZUPHDKFOT-UHFFFAOYSA-N |
| Smiles | O=C(NC3=C(OC)C=CC(Cl)=C3)NC2=CC(C)=NC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.09 | 50 | |
| ethanol | 8.54 | 25 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight341.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.93mL | 14.63mL | 29.26mL |
| 5mM | 0.59mL | 2.93mL | 5.85mL |
| 10mM | 0.29mL | 1.46mL | 2.93mL |
| 50mM | 0.06mL | 0.29mL | 0.59mL |
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