BiologicalActivity
Orallyactiveinsulin-likegrowthfactor1receptor(IGF1R)inhibitorthatexhibitsnoactivityattheinsulinreceptor,FGFR,PDGFRorEGFR.InhibitsIGF1Rautophosphorylation(IC50~1nM),increasesthefractionofcellsintheG2/Mphaseandupregulatesapoptosis.Exhibitsantiproliferativeeffectsinmultiplecancercelllines(IC50=0.05-15μM),andhasanticancerandantineovascularizationactivityinvivo.
TechnicalData
| M.Wt | 414.41 |
| Formula | C22H22O8 |
| Storage | Storeat+4°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 477-47-4 |
| PubChemID | 72435 |
| InChIKey | YJGVMLPVUAXIQN-HAEOHBJNSA-N |
| Smiles | O=C3OC[C@]([C@@]([H])3[C@@H]4[C@]5=CC(OC)=C(OC)C(OC)=C5)([H])[C@@H](O)C1=C4C=C(OCO2)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight414.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.41mL | 12.07mL | 24.13mL |
| 5mM | 0.48mL | 2.41mL | 4.83mL |
| 10mM | 0.24mL | 1.21mL | 2.41mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |
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