Tocris GPCR ligands Tocris小分子,Tocris/AG 879/2617/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AG 879/2617/10/10 mg

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Tocris

货号 /

2617/10

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4000-520-616

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Description:TrkAinhibitor

AlternativeNames:TyrphostinAG879

ChemicalName:(2E)-3-[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-2-propenethioamide

Purity:≥99%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofthetyrosinekinaseactivityofnervegrowthfactor(NGF)TrkA.Decreasescellularproliferationinhumanmuscularsarcomacelllines.AlsoinhibitsErbB2andVEGFR-2(IC₅₀valuesareapproximately1μMforboth).

TechnicalData

M.Wt	316.46
Formula	C₁₈H₂₄N₂OS
Storage	Storeat-20°C
Purity	≥99%(HPLC)
CASNumber	148741-30-4
PubChemID	5487525
InChIKey	LCUMYVYIHXYBIA-FOWTUZBSSA-N
Smiles	CC(C)(C)C1=CC(/C=C(C#N)/C(N)=S)=CC(C(C)(C)C)=C1O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	31.65	100
	ethanol	7.91	25

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight316.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	3.16mL	15.8mL	31.6mL
5mM	0.63mL	3.16mL	6.32mL
10mM	0.32mL	1.58mL	3.16mL
50mM	0.06mL	0.32mL	0.63mL

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