美国Tocris公司 Tocris Bioscience授权代理商，正品,Tocris/AV 412/4397/10/10 mg,激酶,酶,蛋白类,,Tocris Bioscience蚂蚁淘商城

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Tocris/AV 412/4397/10/10 mg

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Tocris

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4397/10

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Description:PotentinhibitorofEGFR,ErbB2andAblreceptortyrosinekinases

ChemicalName:N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-methyl-3-(4-methyl-1-piperazinyl)-1-butyn-1-yl]-6-quinazolinyl]-2-propenamide

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentinhibitorofEGFR,ErbB2andAblreceptortyrosinekinases(IC₅₀valuesare0.5-2,19and41nM,respectively).AlsoweakinhibitorofFLT1andSrc.InhibitsEGFRandErbB2autophosphorylationinvitroinNSCLCandT-47Dbreastcancercelllines,respectively.InhibitstumorgrowthofEGFR-overexpressingA431andErbB2overexpressingBT-474tumorxenograftsinmice.

TechnicalData

M.Wt	507
Formula	C₂₇H₂₈ClFN₆O
Storage	Storeat-20°C
Purity	≥98%(HPLC)
CASNumber	451492-95-8
PubChemID	9806229
InChIKey	ZAJXXUDARPGGOC-UHFFFAOYSA-N
Smiles	FC(C=C1)=C(Cl)C=C1NC2=NC=NC3=CC(C#CC(C)(C)N4CCN(C)CC4)=C(NC(C=C)=O)C=C32

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	1eq.HCl	10.14	20
	DMSO	50.7	100
	ethanol	25.35	50

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight507.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	1.97mL	9.86mL	19.72mL
5mM	0.39mL	1.97mL	3.94mL
10mM	0.2mL	0.99mL	1.97mL
50mM	0.04mL	0.2mL	0.39mL

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