PurifiedAnti-PtdIns(3,4,5)P3monoclonalantibodyconjugatedwithhorserADIshperoxidase.Subclass:IgMSource:MouseApplications:ELISA,Immunofluorescence
ProductBackground:Phosphoinositides(PIPns)areminorcomponentsofcellularmembranesbutareintegralsignalingmoleculesforcellularcommunication.Phosphatidylinositol3,4,5-trisphosphate(PIP3),formedfromPI(4,5)P2thoughphosphorylationbyPI3-kinase,activatesnumeroussignalingpathwaysresultingincellproliferation,growth,survival,glucosetransportandproteinsynthesis.HighPIP3levelsfromdisregulationofPI3-Khavebeendemonstratedincancerandinflammatorydiseases.PIP3ishydrolyzedbythephosphatasesPTENtoPI(4,5)P2andSHIPtoPI(3,4)P2.
Storage
2-8°Cforupto30days,-20°Cforgreaterthan30days.Donotfreezethawmultipletimes.
FeaturedinPublications
1)Garcia-SanFrutos,M.,T.Fernandez-Agullo,etal.(2007).“ImpairedcentralinsulinresponseinagedWistarrats:roleofadiposity.”Endocrinology148(11):5238-47.
Productkeywords:PIP3,PI(3,4,5)P3,PtdIns(3,4,5)P3,IgM,anti-PIP3
Documents
TechnicalDataSheet
| Categories | Antibodies&Proteins |
|---|---|
| Filter | Antibody,LipidBinding,PI(3,4,5)P3 |
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