Tocris/VU 0357121/4437/50/50 mg
Biological Activity
Positive allosteric modulator of mGlu5 receptors (EC50 = 33 nM). Binds to a site distinct from that bound by MPEP (Cat. No. 1212).
Technical Data
| M. Wt | 305.32 |
| Formula | C17H17F2NO2 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 433967-28-3 |
| PubChem ID | 2296132 |
| InChI Key | AHCYOTLTLQTPSU-UHFFFAOYSA-N |
| Smiles | O=C(NC2=C(F)C=C(F)C=C2)C1=CC=C(OCCCC)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 30.53 | 100 |
| ethanol | 30.53 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 305.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.28 mL | 16.38 mL | 32.75 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
| 10 mM | 0.33 mL | 1.64 mL | 3.28 mL |
| 50 mM | 0.07 mL | 0.33 mL | 0.66 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Hammond et al (2010) Discovery of a novel chemical class of mGlu5 allosteric ligands with distinct modes of pharmacology. ACS Chem.Neurosci. 1 702 PMID: 20981342
Keywords: VU 0357121, supplier, VU0357121, pams, positive, allosteric, modulators, mglu5, receptors, mglur5, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
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