加氧酶/氧化酶 |酵素 | Tocris 生物科学,Tocris/CPPG/0972/50/50 mg
Biological Activity
Potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). A much less potent antagonist at group I receptors in neonatal rat cortical slices (KB = 0.65 ± 0.07 nM). Also available as part of the Group III mGlu Receptor Tocriset™.
Technical Data
| M. Wt | 271.21 |
| Formula | C11H14NO5P |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 183364-82-1 |
| PubChem ID | 2878 |
| InChI Key | IGODGTDUQSMDQU-UHFFFAOYSA-N |
| Smiles | NC(C2CC2)(C(O)=O)C1=CC=C(P(O)(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| 1eq. NaOH | 27.12 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 271.21. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.69 mL | 18.44 mL | 36.87 mL |
| 5 mM | 0.74 mL | 3.69 mL | 7.37 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Certificate of Analysis / Product DatasheetSafety DatasheetSelect another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Jane et al (1996) Potent antagonists at the L-AP4- and (1S, 3S)-ACPD-sensitive presynaptic metabotropic glutamate receptors in the neonatal rat spinal cord. Neuropharmacology 35 1029 PMID: 9121605
Toms et al (1996) The effects of (RS)-α-cyclopropyl-4-phosphonophenylglycine ((RS)-CPPG), a potent and selective metabotropic glutamate receptor antagonist. BrJ.Pharmacol. 119 851 PMID: 8922731
Kemp et al (1996) α-Methyl-3-phosphonophenylglycine and α-cyclopropyl-4-phosphonophenylglycine are potent antagonists at mGluRs negatively coupled to adenylyl cyclase. Br.J.Pharmacol. 117 (in press) PMID:
Keywords: CPPG, supplier, potent, group, III, Antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGlu4R, mGlu6R, mGlu7R, mGlu8R, Glutamate, Metabotropic, Glutamate, (Metabotropic), Group, III, Receptors, Glutamate, (Metabotropic), Group, III, Receptors, Tocris Bioscience
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