ZIP Supplier | CAS 863987-12-6 | z-Pseudosubstrate inhibitory peptide | Tocris Bioscience
Novel, cell-permeable inhibitor of protein kinase M (PKM ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKM -induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 M) and produces persistent loss of 1-day-old spatial memory following central administration in vivo.
Control Peptide and Biotinylated Peptide also available.
[H]N([C@@H](CO)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(O)=O)C(=O)CCCCCCCCCCCCC上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
关键词: ZIP, ZIP supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, z-Pseudosubstrate, inhibitory, peptide, Kinase, 2549, Tocris Bioscience
et al (2019)Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science 363 PMID:30545844Grosso et al (2015)The higher order auditory cortex is involved in the assignment of affective value to sensory stimuli. Nat Commun 6 8886 PMID:26619940et al (2013)Prkcz null mice show normal learning and memory. Nature 493 416 PMID:23283171Mirza et al (2017)Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment. JCI Insight 2 PMID:29093271Balaban et alHomolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222 PMID:26157359et al (2015)Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767 PMID:26457205Chen et al (2015)Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047 PMID:25761958Laferrière et al (2011)PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99 PMID:22185613$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
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Cat. No. 7050 Dual cdk4/cdk6 inhibitor; orally bioavailableBio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.Bio-TechneWHERE SCIENCE INTERSECTS INNOVATIONTM
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