其他还原酶 |还原酶 | Tocris 生物科学,NF-kB/IkB | Tocris Bioscience
NF- B (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in the cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immunological response to infections.
NF- B (nuclear factor-kappa B) is a rapidly acting primary transcription factor found in all cell types. It is involved in cellular responses to stimuli such as cytokines and stress and plays a key role in regulating the immune response to infection. In unstimulated cells NF- B dimers are sequestered inactively in the cytoplasm by a protein complex called inhibitor of kappa B (I B). I B inactivates NF- B by masking the nuclear localization signals (NLS).
Activation of NF- B occurs via degradation of I B, a process that is initiated by its phosphorylation by I B kinase (IKK). Phosphorylated I B becomes dissociated from NF- B, unmasking the NLS. Phosphorylation also results in I B ubiquitination and targeting to the proteasome. NF- B can now enter the nucleus and regulate gene expression. NF- B turns on expression of I B forming a negative feedback loop.
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