Tocris/QAQ dichloride/5470/50/50 mg
Biological Activity
Photoswitchable Nav, Cav and Kv channel blocker. Blocks channels in the trans conformation. Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Normally membrane impermeant, but enters nociceptive neurons via ion channels activated by noxious stimuli, particularly TRPV1. Exhibits optically reversible local anesthesia in rats.
Technical Data
| M. Wt | 567.59 |
| Formula | C28H44Cl2N6O2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 91826091 |
| InChI Key | VHURBRSYOFCHNY-UHFFFAOYSA-N |
| Smiles | O=C(C[N+](CC)(CC)CC)NC(C=C2)=CC=C2/N=N/C1=CC=C(NC(C[N+](CC)(CC)CC)=O)C=C1.[Cl-].[Cl-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 5.68 | 10 |
| water | 28.38 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 567.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 1.76 mL | 8.81 mL | 17.62 mL |
| 5 mM | 0.35 mL | 1.76 mL | 3.52 mL |
| 10 mM | 0.18 mL | 0.88 mL | 1.76 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.35 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Mourot et al (2012) Rapid optical control of nociception with an ion-channel photoswitch. Nat.Methods 9 396 PMID: 22343342
Banghart MR et al (2009) Photochromic blockers of voltage-gated potassium channels. Angew.Chem.Int.Ed. 48 9097 PMID: 19882609
Keywords: QAQ dichloride, supplier, photoswitchable, Kv, potassium, channels, K+, blockers, Ca2+, Cav, calcium, Na+, Nav, sodium, local, anesthesia, anesthetic, ligands, Photoswitchable, Ligands, Voltage-gated, Calcium, Channels, Voltage-Gated, Potassium, Channels, Voltage-gated, Sodium, Channels, Photoswitchable, Ligands, Tocris Bioscience
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