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Bpsbioscience/Tau-441 (K257T) Protein/90345/20 μg
2025-05-10
Species: Human Host Species: E. coli MW: 64 kDa Genbank #: P10636-8 Tag(s): No Tag a.a: full length Background:Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimers disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2). Description:Human Tau-441 with a K257T mutation, GenBank Accession No. P10636-8, full length, expressed in an E. coli expression system. MW = 64 kDa. Synonym(s): Tau-F, (N2R4), Tau-4, MAPT, MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549 Formulation: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol. Storage / Stability: Store product at –80°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Application(s): Kinase Assay, Western Blot Reference(s): 1. Zilka, N., et al. Truncated tau from sporadic Alzheimers disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.
2. Rial, A. et al: Calcium Dyshomeostasis in -Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.
Scientific Category: Neuroscience Product Type: Protein Data shown is lot-specific. Contact us for specific information on other lots.本文链接： https://www.ebiomall.cn/b166-bps/info-1451862855.html
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