新闻动态
Bpsbioscience/LDN-57444/27706-1/10 mg
2024-05-03
MW: 397.6 Da CAS Registry #: 668467-91-2 Formula: C17H11Cl3N2O3 Description:LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 μM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration. Synonym(s): 1H–Indole–2,3–dione, 5–chloro–1–[(2,5–dichlorophenyl)methyl]–, 3–(O–acetyloxime) Purity: ≥98% by TLC. Solubility: Soluble in DMSO (20 mg/ml) Format: Yellow powder Storage / Stability:
Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Application(s): Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies. Reference(s): 1. Tan, et al Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318:109 (2008).2. Susor, A., et al., Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1. Reprod. 134:559 - 568, (2007) . Warning(s): Protect from moisture. Avoid freeze/thaw cycles. Scientific Category: Ubiquitin Enzymes Product Type: Inhibitors/Activators Data shown is lot-specific. Contact us for specific information on other lots.本文链接： https://www.ebiomall.cn/b166-bps/info-1471138879.html
免责声明 本文仅代表作者个人观点，与本网无关。其创作性以及文中陈述文字和内容未经本站证实，对本文以及其中全部或者部分内容、文字的真实性、完整性、及时性本站不做任何保证或承诺，请读者仅作参考，并请自行核实相关内容。
版权声明 未经蚂蚁淘授权不得转载、摘编或利用其他方式使用上述作品。已经经本网授权使用作品的，应该授权范围内使用，并注明“来源：蚂蚁淘”。违反上述声明者，本网将追究其相关法律责任。
相关文章
2020-10-05
2020-10-07
2020-10-19
▍
官网分类
▍
品牌问答
