QED Bioscience/DcR1 (ED2)/2299/1 Ea
Anti-DcR1 (ED2) AntibodyORDERING INFORMATION
Catalog No.: 2299
Size: 100ug IgG in PBS, pH 7.4, purified by immunoaffinity chromatography.
BACKGROUNDTRAIL/Apo2L is a new member of the TNF family that induces apoptosis in a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been designated DcR1/TRID/TRAIL- R3/LIT and DcR2/TRAIL-R4/TRUNDD.
DcR1 has an extracellular TRAIL-binding domain but lacks an intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expessed in many normal human tissues but not in most cancer cell lines.
Overexpression of DcR1 does not induce apoptosis but attenuates TRAIL-induced apoptosis.
SPECIFICATION SUMMARYAntigen: Peptide corresponding to aa 111- 123 at the extracellular domain (ED) of human DcR1 precursor (accession no.
AAB67104).
Host Species: Rabbit
Stabilizers: None
Preservatives: 0.02% sodium azide.
SPECIFICITYThis antibody recognizes human, mouse, and rat DcR1 (65kDa).
APPLICATIONSImmunoblotting: use at 1ug/ml.
Western blot analysis of DcR1 in HeLa cell (A), mouse
(B) and rat (C) liver tissue lysates with DcR1 antibody at 1μg/ml.
Immunofluorescence: use at 10ug/ml.
Immunofluorescent staining of DcR1 in rat liver tissue with DcR1 antibody at 10μg/ml.
These are recommended concentrations. Enduser should determine optimal concentrations for their applications.
Positive control: Whole cell lysate from HeLa cells.
DILUTION INSTRUCTIONSDilute in PBS or medium which is identical to that used in the assay system.
STORAGE AND STABILITYThis antibody is stable for at least one (1) year at -20oC. Avoid multiple freeze-thaw cycles.
For in vitro investigational use only. Not for use in therapeutic or diagnostic procedures
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