Adipogen/anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)/AG-27B-0018PF-C100/1-蚂蚁淘商城

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Adipogen/anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) (preservative-free)/AG-27B-0018PF-C100/1

2024-04-29

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NTN1

Recombinant Antibody

2F5

Human IgG2λ.

HEK 293 cells

Recombinant human Netrin-1.

Preservative Free

ELISA Functional: Inhibits the activation of human and mouse Netrin-1 to human or mouse receptors DCC or UNC5 (KD antibody-Netrin-1 is 1.5nM).

HumanMouse

Recognizes human and mouse Netrin-1. Does not recognize Netrin-4. Blocks human and mouse Netrin-1 activity on tumor cell lines in vitro and in vivo. Inhibits Netrin-1-enhanced infectivity of Hepatitis C Virus particles.

≥95% (SDS-PAGE)

Protein A-affinity purified.

1mg/ml

Liquid. In PBS containing 10% glycerol.

anti-Netrin-1 (human), mAb (rec.) (blocking) (2F5) is composed of human variable regions (VH and VL) (λ-chain) of immunoglobulin fused to the human lgG2 Fc domain.For negative control see Prod. No. AG-27B-0020PF.

BLUE ICE

+4°C

-20°C

After opening, prepare aliquots and store at -20°C.Avoid freeze/thaw cycles.

Stable for at least 1 year after receipt when stored at -20°C.

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Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serves as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also involved in tumorigenesis by regulating apoptosis. Netrin-1 promotes atherosclerosis by retaining macrophages in the artery wall. Netrin-1 also governs induced pluripotent stem cell (iPS) formation and improves reprogramming efficiency of human and mouse somatic cells by limiting apoptosis mediated by Netrin-1 receptors DCC or UNC5b.

Product References

Netrin-1 regulates somatic cell reprogramming and pluripotency maintenance: D. Ozmandenci, et al.; Nat. Commun.6,7398 (2015)

Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus: M.L. Plissonnier, et al.; PLoS Biol. 14, e1002421 (2016)

Targeting netrin-1/DCC interaction in diffuse large B-cell and mantle cell lymphomas: T. Broutier, et al.; EMBO Mol. Med. 8, 96 (2016)

Netrin-1 acts as a non-canonical angiogenic factor produced by human Wharton’s jelly mesenchymal stem cells (WJ-MSC): C.P. Prieto, et al.; Stem Cell Res. Ther. 8, 43 (2017)

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