单克隆抗 ID |生物基因有限公司,Anti-Drosha抗体-蚂蚁淘商城

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单克隆抗 ID |生物基因有限公司,Anti-Drosha抗体

2026-07-31

Anti-Drosha抗体

产品编号	YB-13033R
英文名称	Drosha
中文名称	核糖核酸酶3/Drosha抗体
别名	DROSHA; Drosha double stranded RNA specific endoribonuclease; Drosha ribonuclease type III; Etohi2; HSA242976; Nuclear RNase III Drosha; p241; Protein Drosha; Putative protein p241 which interacts with transcription factor Sp1; Putative ribonuclease III; RANSE3L; Ribonuclease 3; Ribonuclease III; Ribonuclease III nuclear; Ribonuclease type III nuclear; RibonucleaseIII; RN 3; RN3; RNase 3; RNase III; RNase3; RNASE3L; RNaseIII; RNASEN; RNC_HUMAN; RNase III Drosha.
规格价格	100ul/1380元购买200ul/2200元购买大包装/询价
说明书	100ul200ul
研究领域	肿瘤细胞生物染色质和核信号表观遗传学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human,Mouse,Rat,Dog,Cow,Horse,Sheep,
产品应用	WB=1:500-2000ELISA=1:500-1000IHC-P=1:400-800IHC-F=1:400-800ICC=1:100-500IF=1:100-500（石蜡切片需做抗原修复）not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
分子量	160kDa
细胞定位	细胞核
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human Drosha/RNase III Drosha:751-850/1374
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background:The ribonuclease III superfamily represents a structurally distinct group of double-strand-specific endonucleases with essential roles in RNA maturation, RNA decay, and gene silencing. Initial cleavage of microRNAs is catalysed by Drosha, a nuclease of the RNase III family, which acts on primary miRNA transcripts (pri-miRNAs) in the nucleus. Human Drosha is a component of two multi-protein complexes. The larger complex contains multiple classes of RNA-associated proteins including RNA helicases, proteins that bind double-stranded RNA, novel heterogeneous nuclear ribonucleoproteins and the Ewings sarcoma family of proteins. The smaller complex is composed of Drosha and the double-stranded-RNA-binding protein, DGCR8.Function:Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3 and 5 strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.Subunit:Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8. The microprocessor complex may contain multiple subunit of DGCR8 and DROSHA. Interacts with DGCR8, SP1 and SNIP1. Interacts with SRRT/ARS2.Subcellular Location:Nucleus. Nucleus; nucleolus. A fraction is translocated to the nucleolus during the S phase of the cell cycle. Localized in GW bodies (GWBs), also known as P-bodies.Tissue Specificity:Ubiquitous.Similarity:Contains 1 DRBM (double-stranded RNA-binding) domain.Contains 2 RNase III domains.SWISS:Q9NRR4Gene ID:29102Database links: Entrez Gene: 29102Human Entrez Gene: 14000Mouse Omim: 608828Human SwissProt: Q9NRR4Human SwissProt: Q5HZJ0Mouse Unigene: 97997Human Unigene: 293142Mouse Important Note:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.Dircer和Drosha是两种核糖核酸酶是卵巢癌细胞中RNA干扰机制中的关键酶，Dircer和Drosha两种酶的表达（数量）越高，存活时间越长。美国科学家研究发现，卵巢癌患者存活率与两种酶有关。美国MD安德森癌症治疗中心先后对111个和132个卵巢癌样本进行了分析。结果发现，人体内两种核糖核酸酶Dicer和Drosha含量高的患者平均存活11年，而含量低的患者平均只能活2.86年。Dicer的水平高低对卵巢癌患者尤其重要。这一发现有助于卵巢癌的诊断和治疗。卵巢恶性肿瘤的发病率在女性常见恶性肿瘤中占2.4%～5.6%，在女性生殖道恶性肿瘤中占第三位。在妇女生殖道癌瘤中，卵巢癌造成的死亡人数高居首位。
产品图片	Sample:Liver(Mouse) Lysate at 30 ugPrimary: Anti- Drosha (bs-13033R) at 1/300 dilutionSecondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilutionPredicted band size: 160 kDObserved band size: 160 kD