Adipogen/anti-NFATc1, pAb (IG-205)/AG-25T-0110-C050/50 µg-蚂蚁淘商城

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Adipogen/anti-NFATc1, pAb (IG-205)/AG-25T-0110-C050/50 µg

2025-05-10

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Product Details
Synonyms	Nuclear Factor of Activated T Cells; Cytoplasmic 1; NFAT Transcription Complex Cytosolic Component; NF-ATc1
Product Type	Polyclonal Antibody
Properties
Source/Host	Rabbit
Immunogen/Antigen	Recombinant N-terminal human NFATc1 fragment fused to a GST-tag.
Application	ChIP: (1:200) Band shift assay: Competes with probe for NFAT binding. Immunocytochemistry: Immunohistochemistry: Immunoprecipitation: (1:200) Western Blot: (1:500-1:1000) Optimal conditions must be determined individually for each application.
Crossreactivity	Human
Specificity	Recognizes all known human NFATc1 isoforms.
Purity	Antigen affinity purified.
Concentration	500μg/ml
Formulation	Liquid. In PBS containing 1mg/ml BSA and 0.02% sodium azide.
Accession Number	UniProt ID O95644: NFATc1
Shipping and Handling
Shipping	BLUE ICE
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

NFATc1 plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 or IL-4 gene transcription. It controls gene expression in embryonic cardiac cells. Regulates not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells.

Product References

Pim-1 kinase enhances NFATc activity and neuroendocrine functions in PC12 cells: M. Glazova, et al.; Mol. Brain Res. 138, 116 (2005)
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines: M. Klein, et al.; J. Immunol. 177, 6667 (2006)
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signaling: A. Akimzhanov, et al.; Am. J. Pathol. 172, 215 (2008)
Cyclic AMP-induced Chromatin Changes Support the NFATc-mediated Recruitment of GATA-3 to the Interleukin 5 Promoter: S. Klein-Hessling, et al.; J. Biol. Chem. 283, 31030 (2008)
Stimulation of interleukin-13 expression by human T-cell leukemia virus type 1 oncoprotein Tax via a dually active promoter element responsive to NF-κB and NFAT: K. Silbermann, et al.; J. Gen. Virol. 89, 2788 (2008)
Sumoylation of the Transcription Factor NFATc1 Leads to Its Subnuclear Relocalization and Interleukin-2 Repression by Histone Deacetylase: A. Nayak, et al.; J. Biol. Chem. 284, 10935 (2009)
NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network: S. Bhattacharyya, et al.; J. Exp. Med. 208, 823 (2011)
NFATc1 induction in peripheral T and B lymphocytes: M. Hock, et al.; J. Immunol. 190, 2345 (2013)
An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development: A.K. Patra, et al.; Nat. Immunol. 14, 127 (2013)