Tocris型号参数规格 Tocris Bioscience一级代理,Tocris/AEG 40730 dihydrochloride/5330/10/10 mg,细胞凋亡,细胞研究,细胞相关,,Tocris Bioscience蚂蚁淘商城

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Tocris/AEG 40730 dihydrochloride/5330/10/10 mg

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Tocris/AEG 40730 dihydrochloride/5330/10/10 mg

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Tocris

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5330/10

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Description:IAPantagoNIST;inducesapoptosis

ChemicalName:222,Trifluoro-N-[[(2S)-1-(N-methyl-L-analyl-L-threonyl)-2-pyrrolidinyl]methyl]-N-(2-phenylethyl)acetamide,diethyletherwith2,4-hexADIyne-1.6-dioldihydrochloride

Purity:≥98%(HPLC)

BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

IAPantagonist;bindstotheBIR3domainofcIAP1,cIAP2andXIAPwithnanomolaraffinity.ReducescIAP1,cIAP2andXIAPproteinlevelsinhumanbreastcancerMDA-MB-231cells.InducesapoptosisincombinationwithTNF,andpotentiatesTRAIL-mediatedapoptosisinhumancolorectalcarcinomaHCT116cells.Cellpermeable.

TechnicalData

M.Wt	1120.06
Formula	C₅₂H₆₈F₆N₈O₈.2HCl
Storage	Storeat-20°C
Purity	≥98%(HPLC)
PubChemID	91826085
InChIKey	CDGBXBVDDLOZGF-CLHBFWEXSA-N
Smiles	O=C([C@H](C)NC)N[C@@H]([C@H](OCC#CC#CCO[C@H](C)[C@H](NC([C@H](C)NC)=O)C(N2[C@H](CN(CCC3=CC=CC=C3)C(C(F)(F)F)=O)CCC2)=O)C)C(N1[C@H](CN(C(C(F)(F)F)=O)CCC4=CC=CC=C4)CCC1)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

	Solvent	MaxConc.mg/mL	MaxConc.mM
Solubility
	DMSO	112.01	100
	water	112.01	100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1120.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass	1mg	5mg	10mg
1mM	0.89mL	4.46mL	8.93mL
5mM	0.18mL	0.89mL	1.79mL
10mM	0.09mL	0.45mL	0.89mL
50mM	0.02mL	0.09mL	0.18mL

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