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Description
Details
Description:Mouse monoclonal antibody to human cluster of differentiation 3 (CD3) antigen
Purification: Prootein G affinity purified
Product Type:Primary antibody
Target Protein:Human peripheral T cell CD3 antigen
Immunogen:Human peripheral T lymphocytes
Fusion Myeloma:Sp2/0-Ag14
Specificity:This antibody recognizes human peripheral blood T cell CD3 antigen.
Reactivity: Human, others not tested
Host / Isotype:Mouse, IgG2a Kappa
Formulation:Lyophilized from a solution in 0.01M PBS pH7.2
Reconstitution:Double distillated water is recommended to adjust the final concentration to 1.00mg/mL.
Storage: Store at -20oC
Research Area:Immunology and Oncology
Background:
CD3 is a surface marker expressed on the cell membrane of all matured T-cells and is virtually not found on the surface of other cells. Therefore, CD3 is used as a T-cell specific marker. In addition, CD3 is involved with T-cell activation by functioning as a co-receptor in the T-cell receptor complex (which is comprised of T cell receptor, ζ-chain and CD3).
Applications:Immuno-fluorescence Staining
References:
1. Kebing Wang et al., Dendritic cells transduced with a PSMA-encoding adenovirus and cocultured with autologous cytokine-induced lymphocytes induce a specific and strong immune response against prostate cancer cells. Urologic Oncology: Seminars and Original Investigations 27 (2009) 26–32.
2. Jun Pang et al., Enhanced antitumor effects by the coculture of allotumor RNA-pulsed dendritic cells with autologous cytokine-induced killer cells on hormone-refractory prostate cancer. Cancer Investigation, 25:527–534, 2007.
3. Jian Wang et al., Inducible Costimulator (ICOS) Enhances the Cytolytic Activity of Cytokine-Induced Killer Cells Against Gallbladder Cancer In Vitro and In Vivo. Cancer Investigation, 27:244–250, 2009.
If research is published using this product, please inform Anogen in order to cite the reference on this datasheet. Anogen will provide one unit of product in the same category as gratitude.
Additional
Additional Information
| Product Specificity | mAb anti-Human CD3, JXT3 |
|---|---|
| Application | IF |
| Size | 0.1 mg |
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是这个文献nanomedicine 2009；5:73-82
Karmali写的
神经胶质细胞（neuroglia cell）简称神经胶质（neuroglia ）,广泛分布于中枢和周围神经系统.普通染色只能显示胞核,用特殊银染方法才能显示神经胶质细胞整体形态.神经胶质细胞一般较神经细胞小,突起多而不规则,数量约为神经细胞的十倍.多分布在神经元胞体、突起以及中枢神经毛细血管的周围.神经胶质细胞具有支持.一营养、保护、髓鞘形成及绝缘,并有分裂增殖与再生修复等多种作用.
（－）中枢神经系统的神经胶质细胞
1．星形胶质细胞（astrocyte）是胶质细胞中最大的一种,胞体呈星形,核大呈圆形或椭圆形,染色较浅.胞质内有交织走行的神经胶质丝（neuroglial filament）.由胞体伸出许多呈放射状走行的突起,部分突起末端膨大形成脚板（end foot）,附着在毛细血管基膜上,或伸到脑和脊髓的表面形成胶质界膜（gliolimitan）.星形胶质细胞约占全部胶质细胞的20％.星形
胶质细胞依其分布及结构又可分为两种.
（1）原浆性星形胶质细胞（protoplasmie astrocyte）:分布于中枢神经系统的灰质内,位于神经细胞体及其突起的周围.原浆性星形胶质细胞的突起不规则,分支多而短曲,表面不光滑.胞质内的神经胶质丝少.
（2）纤维性星形胶质细胞（fibrous astrocyte）:分布于白质内,位于神经纤维之间.其突起呈放射状,细长而直,分支少,表面光滑.胞质内有许多交织排列的原纤维,其超微结构是一种中间丝,称神经胶质丝,其内含有胶质原纤维酸性蛋白（glial fibrillary acidic protein GFAP）,用免疫细胞化学染色技术能特异性地显示出这类细胞.
星形胶质细胞含有高浓度的K+,并能摄取某些神经递质（如γ-氨基丁酸）.它通过调节细胞间隙的K+和神经递质浓度,来影响神经元的功能活动.因此,星形胶质细胞对维持神经细胞微环境的稳定和调节代谢过程起重要作用.当中枢神经系统损伤时,星形胶质细胞迅速分裂增殖,以形成胶质瘢痕形式进行修复.
Thy-1、c-kit散在分布于HB组织中,主要集中在汇管区,而正常肝脏组织中不表达;CD34及SCF在HB中的表达明显高于正常肝脏组织(P0.05),其中CD34主要在血管内皮系统中分布,SCF主要表达在汇管区;CD56表达于成簇的神经纤维组织中,在HB及正常肝脏组织中表达差异无统计学意义(P0.05)。结论不同干细胞相关表面标志物分布于HB组织中,并且集中表达在特定区域。表达Thy-1/c-kit阳性细胞可能对HB的发生起一定作用。
