Thescanningtranslationinitiationmodelsuggeststhat40Sribosomalsubunitpreloadedwithfactorsbindtothe5’endofthemRNAnearthecap.The48SsubunitmovesalongthemRNAuntilitfindstheinitiationtripletandincomplexwithtRNAand60Ssubunitformedthefirstpeptidebond.TranslationcontrolismostlyregulatedattheproteininitiationstepthroughtranslationinitiationfactorssuchaseIF2oreIF4. Contributor:CellSignaling REFERENCES:DeverT.E.(1999)Translationinitiation:adeptatadapting.TrendsBiochem.Sci.24,398-403.GingrasACetal.(1999)eIF4initiationfactors:effectorsofmRNArecruitmenttoribosomesandregulatorsoftranslation.Annu.Rev.Biochem.68,913-963.Gray,N.K.andWickens,M.(1998)Controloftranslationinitiationinanimals.Annu.Rev.CellDev.Biol.14,399-458.Palfrey,H.C.andNairn,A.C.(1995)Calcium-dependentregulationofproteinsynthesis.Adv.SecondMessengerPhosphoproteinRes.30,191-223.Rhoads,R.E.(1999)Signaltransductionpathwaysthatregulateeukaryoticproteinsynthesis.J.Biol.Chem.274,30337-30340.
