Human CD166 is a type 1 glycoprotein expressed on activated T cells, B cells and monocytes and appears to be the ligand for CD6 (1,2). Human CD166 may be important for activation of T cells.
Isotype: Murine IgG1
Immunogen: Human thymic epithelial cells
Specificity: Antibody 3A6 recognizes the CD166 molecule of 100 kd. It is cross reactive with bovine CD166 (8).
Functional Application: Antibody 3A6 blocks binding of CD6 to CD166. Antibody 3A6 has been used to identify mesenchymal progenitor cells populations (5,6).
References:
1. M.A. Bowen, et al, (1995) J Exp Med 181: 2213-2220.
2. M.A. Bowen, et al, (1996) J Biol Chem 271: 17390-17396.
3. Leukocyte Typing VI (T. Kishimoto, et al, eds.) Garland Publishing, Inc., New York (1997) p. 459-465.
4. Spaggiari G.M., L. Moretta, et al. (2006) Blood 107(4): 1484-1490.
5. K Richardson, I.M. Khan, C.W. Archer (2006) Eur Cell & Materials 12 (suppl 1): 70.
6. R Williams, HE McCathy, et al. (2010) PLoS ONE 5(10): e13246 doi:10.1371.
7. O Ozbey, I Ustunel, et al. (2014) Acta Histochem 116(5): 763-70.
8. A Konno, W C Davis, et al. (2001) J Leuk Biol 69: 944-950.
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Author:AndrewJ.Hall,MilenaQuaglia,PanagiotisManesiotis,ErsiliaDeLorenzi,andBörjeSellergren
Resource:AnalyticalChemistry,2006,78(24):8362-8367.
Abstract:
Arangeof2-acrylamidopyridines,showingsubtledifferencesinsolutionbindingtowardcarboxylicacids,hasbeeninvestigatedasfunctionalmonomersinmolecularimprinting.ImprintingofN-Z-L-glutamicacidwithonesuchmonomerisshowntobeeffectiveinthecreationofamolecularlyimprintedpolymer(MIP)withrecognitionpropertiesforitstemplateandalsoforlargermoleculescontainingglutamicacidresidues.IncomparisontoaMIPpreparedviaamore"trADItional"approach,thenewpolymericreceptorsexhibitreducednonspecificbinding.Thenewreceptorsarecomparedwithpreviouslyreportedurea-basedreceptorstargetingtheglutamicacidresidueandreceptorstargetingthepteridinesubstructureoffolicacid.
PMID:17165828
免疫组化多聚物法
immunohistochemistry
英[ɪmjʊnəʊhɪstəʊ'kemɪstrɪ]
美[ɪmjʊnoʊhɪstoʊ'kemɪstrɪ]
[词典]免疫组织化学;
[例句]Methods Transmission electron microscope and immunohistochemistry were used.
方法采用透射电镜和免疫组化法。
苏州高分子科学先进材料有限公司
polymer英[ˈpɒlɪmə(r)]美[ˈpɑ:lɪmə(r)]
n.多聚物; [高分子] 聚合物;
[例句]The nature of the polymer is currently a trade secret.
这一聚合物的性质目前是个商业机密。
[其他]复数:polymers

