Title:PolymericReceptorsfortheRecognitionofFolicAcidandRelatedCompoundsviaSubstructureImprinting
Author:AndrewJ.Hall,MilenaQuaglia,PanagiotisManesiotis,ErsiliaDeLorenzi,andBörjeSellergren
Resource:AnalyticalChemistry,2006,78(24):8362-8367.
Abstract:
Arangeof2-acrylamidopyridines,showingsubtledifferencesinsolutionbindingtowardcarboxylicacids,hasbeeninvestigatedasfunctionalmonomersinmolecularimprinting.ImprintingofN-Z-L-glutamicacidwithonesuchmonomerisshowntobeeffectiveinthecreationofamolecularlyimprintedpolymer(MIP)withrecognitionpropertiesforitstemplateandalsoforlargermoleculescontainingglutamicacidresidues.IncomparisontoaMIPpreparedviaamore"tr
ADItional"approach,thenewpolymericreceptorsexhibitreducednonspecificbinding.Thenewreceptorsarecomparedwithpreviouslyreportedurea-basedreceptorstargetingtheglutamicacidresidueandreceptorstargetingthepteridinesubstructureoffolicacid.
PMID:17165828