ProductDescription
NanosoftPolymersoffersDSPE-PEG-Folate(DSPE-PEG-FOL)conjugate,whichcanbeincorporatedintoliposomesasatargetingligand.FolatereceptorsarecellularsurfaceMarkersfornumeroussolidtumorsandmyeloidleukemias.
Folatetargeteddrugdeliveryhasemergedasanalternativetherapyforthetreatmentandimagingofmanycancersandinflammatorydiseases.Duetoitssmallmolecularsizeandhighbindingaffinityforcellsurfacefolatereceptors(FR),folateconjugateshavetheABIlitytodeliveravarietyofmolecularcomplexestopathologiccellswithoutcausingharmtonormaltissues.ComplexesthathavebeensuccessfullydeliveredtoFRexpressingcells,todate,includeproteintoxins,immunestimulants,chemotherapeuticagents,liposomes,nanoparticles,andimagingagents.ThisreviewwillsummarizetheapplicationsoffolicacidasatargetingligandandhighlightthevariousmethodsbeingdevelopedfordeliveryoftherapeuticandimagingagentstoFR-expressingcells.


